Following up on the success of the V 200.0, orders were placed with Krauss-Maffei in 1960 for the construction of the class V 200.1. Designed for both heavy passenger and freight service, the already proven design principles of the V 200.0 were to be applied, however with increased performance 1,986 kilowatts (2,700 horsepower). The first unit was placed into service on November 27, 1962 and the first 20 units of the class V 200.1 were running on the route from Lindau to Munich starting in the summer of 1963. A total of 50 locomotives were delivered by 1965. In 1968, the class V 200.1 was given the new designation of class 221. Over time the area of use changed. These locomotives were still in express service in the beginning but they gradually moved over to being the motive power for heavy freight trains in the North and West of Germany.